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目的探讨细胞间黏附分子(ICAM-1)、P-选择素(P-selectin)、D二聚体(D-dimer)在子痫前期发生发展中的作用。方法随机选取子痫前期患者39例为研究组,37例正常妊娠孕妇为对照组,采用免疫组织化学技术检测两组胎盘组织中ICAM-1、P-selectin的表达情况;采用酶联免疫吸附法(ELISA)检测两组血浆ICAM-1、P-selectin和D-dimer的表达水平。结果子痫前期组胎盘ICAM-1、P-selectin的表达明显高于对照组(P<0.05);两组血浆均有ICAM-1、P-selectin和D-dimer的表达,子痫前期组的血浆ICAM-1、P-selectin和D-dimer表达明显高于对照组(P<0.05)。结论子痫前期患者ICAM-1、P-selectin和D-dimer表达升高可能与子痫前期的发生发展有关,监测这些指标对病情判断及指导治疗具有重要意义。
Objective To investigate the role of intercellular adhesion molecule-1 (ICAM-1), P-selectin and D-dimer in the development of preeclampsia. Methods 39 cases of preeclampsia were randomly selected as research group and 37 normal pregnant women as control group. The expression of ICAM-1 and P-selectin in placenta were detected by immunohistochemical technique. (ELISA) was used to detect the plasma levels of ICAM-1, P-selectin and D-dimer. Results The expression of ICAM-1 and P-selectin in placenta of preeclampsia group was significantly higher than that in control group (P <0.05). The expression of ICAM-1, P-selectin and D-dimer in plasma of both groups was significantly higher than that in control group The expression of ICAM-1, P-selectin and D-dimer in plasma were significantly higher than those in control group (P <0.05). Conclusions The elevated expression of ICAM-1, P-selectin and D-dimer in preeclampsia may be related to the development of preeclampsia. It is of great significance to monitor these indexes in judging the condition and guiding the treatment.