目的通过对行IVF长方案不同卵巢反应患者妊娠结局及影响因素的分析,以期指导临床,及时调整方案,达到个体化治疗。方法由获卵数的不同将491名患者分为高反应组(获卵数>15个n=99)、低反应组(取卵数≤5个n=86)、对照组(5<取卵数≤15,n=306)。对三组的月经第3天、扳机日内分泌水平及受精、妊娠结局进行分析。结果低反应组的年龄、不孕年限较长,FSH用量增加,卵裂率、移植胚胎数、妊娠率均低于对照组,第3天FSH、E2、FSH/LH均高于其他两组。高反应患者虽然在不孕年限、FSH用量、妊娠率及基础内分泌水平与对照组无明显差异,但是卵子成熟率、受精率、优质胚胎率均降低,而流产率、OHSS发生率升高。结论第3天基础卵泡及内分泌水平和扳机日E2、P对妊娠结局均有影响,可以通过第三天卵巢基础状态确定合理用药方案,实行个体化治疗,提高妊娠率。 OBJECTIVE: To analyze the pregnancy outcome and influencing factors of patients with different ovarian response in IVF long-term regimen in order to guide the clinical and timely adjustment of programs to achieve individualized treatment. Methods 491 patients were divided into high response group (number of oocytes> 15 n = 99), low response group (number of oocytes ≤ 5 n = 86) and control group (5