论文部分内容阅读
十八反是中药药性基本理论之一,但是对于其存、废的争论,从汉至今尚未停息。在实验方面,以往的研究基本上仍是以健康动物的急性或亚急性实验为主,有关遗传毒理方面的研究,一直未见报道,为了评价十八反药物配伍的安全性,提供遗传毒理方面的资料,我们选用芫花、甘遂、大戟、甘草等药配伍组成C、L、T、G、丸,应用鼠伤寒沙门氏菌加哺乳动物肝微粒体酶检测系统,以及枯草杆菌重组修复试验对该丸进行了诱变性测试,现报告于后:
Anti-eighteen is one of the basic theories of Chinese herbal medicine, but the debate over its existence and disuse has not yet ceased from the Han. In terms of experiments, previous studies were basically based on acute or subacute tests of healthy animals. Studies on genetic toxicology have not been reported. In order to evaluate the safety of 18 anti-drug compatibility, genetic toxicity is provided. In the aspect of physical information, we used C, L, T, G, and pills to compose the medicines of Flos Sophorae, Kansui, Otsuka, and Glycyrrhiza uralensis, applied Salmonella Typhimurium and mammalian liver microsome enzyme detection system, and reconstructed Bacillus subtilis The test has been tested for mutagenicity of the pill and is now reported here: