目的：评价ＤＤＰ＋５Ｆｕ／ＣＦ＋ＩＮＦ（干扰素）方案治疗晚期鼻咽癌的疗效和毒性反应。方法：本文采用ＤＤＰ＋５Ｆｕ／ＣＦ＋ＩＮＦ（ＤＤＰ２０ｍｇ／ｍ２×５，５Ｆｕ３００ｍｇ～４００ｍｇ／ｍ２×５，ＣＦ２００ｍｇ×５，ＩＮＦ３×１０６Ｕ×３）方案共治疗晚期鼻咽癌２６例；结果：２５例可评价疗效，总有效率（ＣＲ＋ＰＲ）８０％（２０／２５），ＣＲ率１２％，中位缓解期４８月（２～１２月）。在放疗和／或化疗后复发转移的２１例中，ＣＲ２例，ＰＲ１４例，ＣＲ＋ＰＲ７６２％（１６／２１），而曾用ＤＤＰ／ＴＨＰ＋５Ｆｕ／ＣＦ的１１例中，ＰＲ率８１８％（９／１１），无ＣＲ；毒性反应主要是骨髓抑制和消化道反应等，ＷＨＯⅢ＋Ⅳ级毒性比例分别为：ＷＢＣ下降２２％、口腔炎２３７％、恶性呕吐１０１％和腹泻１１９％；结论：作者认为ＤＤＰ＋５Ｆｕ／ＣＦ＋ＩＮＦ联合化疗方案是治疗晚期鼻咽癌的有效方案，值得进一步研究，但毒性明显，需谨慎应用 Objective: To evaluate the efficacy and toxicity of DDP + 5Fu / CF + INF (interferon) regimen in the treatment of advanced nasopharyngeal carcinoma. Methods: 26 patients with advanced nasopharyngeal carcinoma were treated with DDP + 5Fu / CF + INF (DDP 20mg / m2 × 5,5Fu300mg ~ 400mg / m2 × 5, CF200mg × 5, INF3 × 106U × 3). Results: The total effective rate (CR + PR) 80% (20/25), CR rate of 12%, the median remission 4  August (2 ~ December). Of the 21 patients who relapsed and metastasized after radiotherapy and / or chemotherapy, there were CR2, PR14 and CR76% 2 (16/21), while PR rate was 818% (11/21) in 11 patients who used DDP / THP + 5Fu / 9/11), no CR; toxic reactions are mainly myelosuppression and gastrointestinal reactions, WHOⅢ + Ⅳ grade toxicity were: WBC decreased by 22%, stomatitis 237%, malignant vomiting 101% and diarrhea 119 %; Conclusion: The authors believe that DDP +5 Fu / CF + INF combination chemotherapy regimen is an effective treatment of advanced nasopharyngeal carcinoma, worthy of further study, but the toxicity is obvious, need to be cautiously applied