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胰岛素抵抗(Insulin Resistance,IR)指在胰岛素(Insulin,INS)作用的靶组织中,一定量的INS的生物学效应低于预计正常水平。IR既是2型糖尿病的主要发病机制和重要特征,也是高血压、脂质异常、腹型肥胖等心血管疾病危险因素的共同病理生理基础。IR机制的研究已深入到细胞和分子水平。IR机制复杂,近年来对肿瘤坏死因子α(Tumor Necrosis Factor.α,TNF-α)及其受体在IR中的作用备受关注。拟就TNF-α及其受体在IR中的作用综述如下。
Insulin Resistance (IR) refers to the biological effect of a certain amount of INS in the target tissue that is under the action of Insulin (INS), which is lower than the expected normal level. IR is not only the main pathogenesis and important characteristics of type 2 diabetes mellitus, but also the common pathophysiological basis of risk factors of cardiovascular diseases such as hypertension, lipid abnormalities and abdominal obesity. Research on IR mechanisms has gone deep into the cellular and molecular level. IR mechanism is complex. In recent years, attention has been paid to the role of Tumor Necrosis Factor.α (TNF-α) and its receptor in IR. The role of TNF-α and its receptor in IR is outlined below.