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烧伤能损害高龄豚鼠心肌收缩功能。作者应用离体的幼年和老年豚鼠灌流心脏测定了左心室压(LVP)、最高左心室压(+dP/dt max)及最低左心室压(-dP/dtmax)等参数,证明老年豚鼠心脏的LVP、+dP/dt max及-dP/dt max均明显低于对照组。同时证明高龄豚鼠左心收缩功能不全不能被增加心率、细胞外钙浓度和心肌纤维长度以及补液复苏治疗所纠正。作者认为:严重烧伤使高龄鼠原已受损的心脏功能进一步降低,并影响了烧伤休克及液体复苏治疗的效果。
Burn can damage aged guinea pig myocardial systolic function. The authors used parameters of left ventricular pressure (LVP), maximum left ventricular pressure (-dP / dt max) and minimum left ventricular pressure (-dP / dtmax) in isolated perfused heart of young and old guinea pigs. LVP, + dP / dt max and -dP / dt max were significantly lower than the control group. At the same time, it was proved that the left ventricular systolic dysfunction in aged guinea pigs can not be corrected by increasing heart rate, extracellular calcium concentration and myocardial fiber length, and rehydration therapy. The author believes that severe burns further reduce the already impaired heart function of aging rats and affect the effects of burn shock and fluid resuscitation.