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目的 :观察犬连续口服复方萘酚喹的毒性剂量、损伤的靶器官、可逆性及安全剂量范围。方法 :给比格犬口服复方萘酚喹 1 7.5 ,87.5或 1 4 0mg/(kg·d) ,每天 1次 ,连服 1 4d。给药结束后 ,各组活杀 2 /3,留 1 /3继续观察2 8d。观测了临床症状和生理指标 ,血液学 8项、血生化 1 3项、尿 8项、心电图、眼底、骨髓和组织病理学。结果 :主要毒性反应见于 1 4 0mg/(kg·d)组 ,给药后 5 /6只犬出现恶心、呕吐等消化系统症状 ,部分动物出现阵发性抽搐 ,几分钟后自行缓解。该组给药后GOT ,GPT明显升高 ,心电图Q_T间期延长 ,骨髓红系受到抑制 ,组织学检查可见肝细胞损伤明显。 87.5mg/(kg·d)组各种毒性反应均较大剂量组轻 ,所有毒性反应于停药后自行恢复。 1 7.5mg/(kg·d)组未见明显毒副作用。结论 :1 4 0mg/(kg·d)为重度中毒剂量 ,87.5mg/(kg·d)为中度中毒剂量 ,1 7.5mg/(kg·d)为安全剂量。毒性靶器官是肝脏和骨髓 ,损伤是可逆的
Objective: To observe the oral dose of compound naphthoquine, the target organ damage, reversible and safe dose range of oral continuous in dogs. Methods: Beagle dogs were given compound naphthoquine 1 7.5, 87.5 or 140 mg / (kg · d) once daily for 14 days. After the administration, each group killed 2/3, leaving 1/3 to continue to observe 2 8d. Observed the clinical symptoms and physiological indicators, hematology 8, blood biochemistry 1 3, 8 urine, electrocardiogram, fundus, bone marrow and histopathology. Results: The main toxicity was found in 140 mg / (kg · d) group. After administration, 5/6 dogs showed digestive symptoms such as nausea and vomiting. Some animals had paroxysmal convulsions and relieved spontaneously after few minutes. After administration of GOT and GPT, the Q_T interval of electrocardiogram was prolonged, the erythrocyte of bone marrow was inhibited, and histological examination showed obvious hepatocyte injury. 87.5mg / (kg · d) group of various toxic reactions were lighter than the larger dose group, all the toxic reactions recovered after withdrawal. 1 7.5mg / (kg · d) group showed no significant side effects. Conclusion: 140 mg / (kg · d) is a severe poisoning dose, 87.5 mg / (kg · d) is a moderate poisoning dose, and 7.5 mg / (kg · d) is a safe dose. Toxic target organ is the liver and bone marrow, damage is reversible