论文部分内容阅读
目的 :探讨霉酚酸酯 (MMF)治疗慢性移植肾肾病 (CAN)的疗效和安全性。 方法 :回顾性分析应用MMF、联合小剂量环孢素A(CsA)和强地松 (Pred)治疗 9例CAN患者的效果和并发症。 结果 :9例中有 8例患者的血清肌酐 (SCr)下降 ,治疗前和随访时SCr两组间有显著性差异 (P <0 0 5 ) ,有效率达 88% ,其中 2例因严重腹泻而被迫停用MMF。有 1例SCr升高治疗无效 ,转为血液透析。 结论 :MMF、联合小剂量CsA和Pred治疗CAN有一定效果。腹泻是应用MMF的严重副反应 ,影响了MMF的使用 ,值得进一步探讨
Objective: To investigate the efficacy and safety of mycophenolate mofetil (MMF) in the treatment of chronic allograft nephropathy (CAN). Methods: The effects and complications of 9 cases of CAN treated with MMF combined with CsA and prednisone were retrospectively analyzed. Results: Serum creatinine (SCr) was decreased in 8 of 9 patients. There was a significant difference between the two groups (P <0.05) before and at the time of follow-up, with an effective rate of 88%, of which 2 were severe diarrhea Forced to disable MMF. One case of SCr increased treatment ineffective, into hemodialysis. Conclusion: MMF combined with low-dose CsA and Pred treatment of CAN has some effect. Diarrhea is the application of MMF serious side effects, affecting the use of MMF, it is worth further exploration