【摘 要】
：
Based on the active site of lanosterol 14α-demethylase of azole antifungal agents,sixteen 1-(1H-1,2,4-triazole-1-yl)- 2-(2,4- difluorophenyl)-3-(N-n-butyl-N-1-
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
Based on the active site of lanosterol 14α-demethylase of azole antifungal agents,sixteen 1-(1H-1,2,4-triazole-1-yl)- 2-(2,4- difluorophenyl)-3-(N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole)-2-propanols have been designed,synthesized and evaluated as antifungal agents.Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum.
Based on the active site of lanosterol 14α-demethylase of azole antifungal agents, sixteen 1- (1H-1,2,4-triazole-1-yl) -N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole) -2-propanols have been designed, synthesized and evaluated as antifungal agents. Results of preliminary antifungal tests by eight human pathogenic fungi in in vitro showed that some of the compounds show excellent activities with broad spectrum.
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