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目的 :探讨肝纤维化血清标志物Ⅳ型胶原 (Ⅳ -C)、层粘蛋白 (LN)、透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )在肝病诊断中的意义。方法 :采用放射免疫分析 (RIA)对 36 1例肝病患者、5 2例健康体检者血清中Ⅳ -C、LN、HA、PCⅢ进行检测 ,同时与对照组比较。结果 :慢性迁延型肝炎 (CPH)、慢性活动型肝炎 (CAH)、肝炎后肝硬化 (LC)血清中Ⅳ -C、LN、HA、PCⅢ含量与对照组相比均有不同程度升高 (p <0 0 1或p<0 0 0 1 ) ,且随着病程的发展逐渐升高 ,肝硬化时升幅最大 ,其中以HA升高幅度最为明显。结论 :血清Ⅳ -C、LN、HA、PCⅢ测定可较好地反映肝纤维化程度 ,在肝硬化诊断中以HA价值最高
Objective: To investigate the significance of serum markers of type Ⅳ fibrosis (Ⅳ -C), laminin (LN), hyaluronic acid (HA) and type Ⅲ procollagen (Ⅲ) in the diagnosis of liver disease. Methods: Radioimmunoassay (RIA) was used to detect the levels of Ⅳ -C, LN, HA, PC Ⅲ in 361 patients with liver disease and 52 healthy controls. Results: The contents of Ⅳ -C, LN, HA and PCⅢ in patients with chronic persistent hepatitis (CPH), chronic active hepatitis (CAH) and posthepatitic cirrhosis (LC) were all increased to different extents <0 0 1 or p <0 0 0 1), and with the progression of the disease gradually increased, the largest increase in cirrhosis, of which the most significant increase in HA. Conclusion: The serum levels of Ⅳ -C, LN, HA and PCⅢ can reflect the degree of liver fibrosis better, and HA value is the highest in the diagnosis of liver cirrhosis