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目的:研究维生素D治疗骨质疏松的临床效果。方法:选取2012年4月至2013年11月我院的62例骨质疏松患者,利用随机数字表法将患者随机分为观察组和对照组,各31例。对照组采用口服二膦酸盐治疗,观察组采用联合口服维生素D与二膦酸盐治疗,对比两组患者临床效果、生化指标、骨密度以及不良反应等。结果:观察组显效者占70.97%,有效率为93.55%,均显著高于对照组。治疗后两组的血甲状旁激素、血碱性磷酸酶、血钙以及骨密度值均较治疗前显著提高,血钙显著降低,差异均有统计学意义(P<0.05)。药物不良反应两组差异无统计学意义(P>0.05)。结论:单纯使用二膦酸盐无法有效改善骨质疏松症状,维生素D联合二膦酸盐可以有效缓解及改善骨质疏松患者骨量丢失、骨密度过低情况,缓解患者疼痛,降低骨折病发率,值得临床推广。
Objective: To study the clinical effect of vitamin D in treating osteoporosis. Methods: Sixty-two patients with osteoporosis in our hospital from April 2012 to November 2013 were randomly divided into observation group (n = 31) and control group (n = 31) using random number table. The control group was treated with oral bisphosphonates. The observation group was treated with oral administration of vitamin D and bisphosphonates. The clinical effects, biochemical parameters, bone mineral density and adverse reactions were compared between the two groups. Results: The observation group was markedly effective accounted for 70.97%, the effective rate was 93.55%, were significantly higher than the control group. After treatment, the levels of blood parathyroid hormone, blood alkaline phosphatase, serum calcium and bone mineral density in both groups were significantly higher than those before treatment, and the serum calcium was significantly decreased. The differences were statistically significant (P <0.05). There was no significant difference in adverse drug reaction between the two groups (P> 0.05). Conclusion: Biphosphonate alone can not effectively improve the symptoms of osteoporosis. Vitamin D combined with bisphosphonates can effectively relieve and improve the bone loss and bone mineral density in patients with osteoporosis, relieve pain and reduce the incidence of fractures Rate, it is worth clinical promotion.