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为观察连续重复给予仙蝥抗癌片对大鼠产生的毒性反应 ,确定无毒反应剂量 ,评价临床应用的安全性。对大鼠灌胃仙蝥抗癌片连续 3个月 ,3个剂量组分别灌胃 1.0 g、2 .0 g、6 .0 g(生药 ) / kg,灌胃药物体积均为 2ml/ 10 0 g体重。结果 :实验期间无一动物死亡 ,血液学及血液生化学、内脏脏器重量及病理学检查均无毒性变化 ,但大剂量组动物体重较其他组为小。表明仙蝥抗癌片以相当于人等效剂量的 4、8、2 4倍给大鼠灌胃给药 ,小剂量口服长期用药安全 ,而大、中剂量用药则呈现一定的毒副作用。
In order to observe the repeated repeated administration of Xianying Kangai Tablets to rats for toxicity, to determine the non-toxicity dose, and to evaluate the safety of clinical application. Rats were treated with gavage centipede anticancer tablets for 3 consecutive months. The three dose groups were given 1.0 g, 2.0 g, and 6.0 g (crude drug)/kg gavage, respectively, and the volume of drug administered was 2 ml/100%. g weight. RESULTS: None of the animals died during the experiment. There were no toxicological changes in hematology and blood biochemistry, visceral organ weight and pathological examination. However, the animals in the high-dose group had smaller body weight than the other groups. It showed that Xianqi anti-cancer tablets were given to rats by gavage at 4, 8 and 24 times the human equivalent dose. Long-term use of low-dose drugs was safe, while large- and medium-dose drugs showed certain toxic and side effects.