抗精神药物所致的恶性症状群(简称NMS),1960年首先由法国精神科医生报导,距今二十余年。但至1980年为止,国外文献大约只报导了60例,而1980～1986年所报告的病例数几乎为其两倍。本文着重将80年代以来对该症状群认识的进展综述如下,已为大家所熟悉的资料则较少涉及。一、临床情况 1.临床病程:NMS的临床症状包括发热、肌强直、植物神经失调的体征(如高热、心动过速、出汗、血压不稳)和精神状态的改变。Shaler(1986)复习了80篇文献报导的150例NMS,其中120例被他确认为NMS。他发现在用药(包括换药)后,最快的在45分钟就发生NMS,最迟的则在65天后发生。除了上述这两种极端情况外,大多数NMS发生在开始治疗后的数天内(平均4.8天)。90%以上的病例临床症状的充分发展是 The anti-psychotic group of malignant symptoms (referred to as NMS), first reported in 1960 by the French psychiatrist, more than 20 years ago. As of 1980, however, only about 60 cases were reported in foreign literature, while the number reported in 1980-1986 was almost double. This article focuses on the progress made since the 1980s on the understanding of the symptom cluster as follows, which is familiar to everyone. First, the clinical situation 1. Clinical course: clinical symptoms of NMS include fever, myotonia, autonomic dysfunction signs (such as fever, tachycardia, sweating, blood pressure instability) and mental status changes. Shaler (1986) reviewed 80 articles of 150 reported NMS, of which 120 were identified as NMS. He found that after medication (including dressing change), the fastest NMS occurred at 45 minutes and the later at 65 days. With the exception of these two extremes, most of the NMS occurred within a few days after starting treatment (average 4.8 days). More than 90% of cases are fully developed clinical symptoms