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It has been well known that immune function is modulated by endogenous opioid peptides:βendorphin and enkephalins. However, the effect of dynorphin A on the immnune thnction has not been well documented.In this study, we investigated dynorphin A in the regulation of mitogen-induced proliferation and interleukin-2 (IL-2) production of rat splenocytes.The results showed that dynorphin A 1-13 as well as dynorphin A1- 17 enhanced concanavalin A-stimulated ~3H thyrnidine uptake 46%-112 % in a dose-dependent fashion.Dynorphin A also
It has been well known that the immune function is modulated by endogenous opioid peptides: βendorphin and enkephalins. However, the effect of dynorphin A on the immnune thnction has not been well documented. In this study, we investigated dynorphin A in the regulation of mitogen- induced proliferation and interleukin-2 (IL-2) production of rat splenocytes. The results showed that dynorphin A 1-13 as well as dynorphin A1- 17 enhanced concanavalin A-stimulated ~ 3H thyrnidine uptake 46% -112% in a dose- dependent fashion.Dynorphin A also