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采用电生理和药理技术证明,细胞膜上存在三种类型的钙通道,即 T(瞬时)型、N(神经元)型和 L(长程)型。在神经元、心肌、骨骼肌、平滑肌和神经内分泌细胞上可检出含量可变的 L 型和 T 型通道。T 型通道为低电压激活、快速失活通道,流入钙量与流入钡量相等或略高,而 L 型通道则为高电压激活,不失活或缓慢失活通道,它流入的钡量多于钙量。N 型通道仅存在于神经元。T 型通道不受已知的钙通道激动剂、阻滞剂或毒素影响,但可被0.1mmol/L 镍阻断,在某些神经元亦可被0.1mmol/L 苯妥英(phenytoin)阻断。N 型和 L 型通道可被低浓度(20μmol/L)的镉阻断,N 型和神经元
Electrophysiological and pharmacological studies have shown that there are three types of calcium channels on the cell membrane, namely T (transient), N (neuron) and L (long). Variable levels of L and T channels can be detected on neurons, myocardium, skeletal muscle, smooth muscle and neuroendocrine cells. T-channel activation of low voltage, rapid inactivation of channels, influx of calcium and inflow of barium equal or slightly higher, while the L-channel is high voltage activation, not inactivation or slow inactivation of the channel, it flows into the barium and more The amount of calcium. N-type channels exist only in neurons. T-type channels are not affected by known calcium channel agonists, blockers or toxins, but are blocked by 0.1 mmol / L nickel and are also blocked by 0.1 mmol / L phenytoin in some neurons. N-type and L-type channels can be blocked by cadmium at a low concentration (20μmol / L), N-type and neurons