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通过受体相关蛋白（ＲＡＰ）ｃＤＮＡ探针，用组织原位杂文技术首次证明了ＲＡＰｍＲＮＡ在肾小球细胞中的表达。进一步通过ＲＡＰ融会蛋白抗血清的体外间接免疫荧光，免疫电镜和体内结合试验的直接免疫荧光和免疫电镜表明肾小球细胞中表达ＲＡＰ细胞为肾小球上皮足突细胞，循环抗体能与其结合形成免疫复合物并刺激足突细胞内新抗原的不断合成，使得免疫复合物不断增大。从基因水平为Ｈｅｙｍａｎｎ肾炎（ＨＮ）原位免疫复合物形成机理提供了实验依据，也为今后的基因抑制治疗提供了可能性。
The expression of RAP mRNA in glomerular cells was demonstrated for the first time by using the receptor-associated protein (RAP) cDNA probe with tissue in situ hybridization. Furthermore, indirect immunofluorescence, immunofluorescence and immunoelectron microscopy in vitro of indirect immunofluorescence, immunoelectron microscopy and in vivo binding assays of RAP fusion protein antiserum showed that RAP cells were expressed in glomerular cells as glomerular epithelial cells, and circulating antibodies could combine with them to form Immune complexes and stimulate the continuous synthesis of new antigens within the foot process cells, making immune complexes ever-increasing. It provides the experimental basis for the formation mechanism of Heymann Nephritis (HN) in situ immune complex at the gene level, and also provides the possibility for future gene suppression therapy.