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目的观察调胃舒颗粒剂对萎缩性胃炎大鼠血清一氧化氮(NO)含量的影响。方法将SD大鼠随机分为正常对照组(A)、模型组(B)、调胃舒颗粒剂小剂量组(C)、调胃舒颗粒剂大剂量组(D)、三九胃泰治疗组(E),分别处理后观察大鼠体质量改变等一般情况,并测定血清NO含量。结果 C组与D组血清NO含量均显著高于B组与E组(P<0.05);D组显著高于C组(P<0.05)。D组大鼠体质量上升情况显著优于B组、C组、E组。结论调胃舒颗粒剂对萎缩性胃炎大鼠有治疗作用;对血清NO的影响呈量-效关系。
Objective To observe the effect of Tiaoshu Shu granules on serum nitric oxide (NO) content in atrophic gastritis rats. Methods The SD rats were randomly divided into normal control group (A), model group (B), low dose of TGP group (C), high dose of TGP group (D) and Sanjiuweitai Group (E), respectively, after treatment to observe the general situation of rat body mass changes, and determination of serum NO content. Results Serum NO levels in group C and group D were significantly higher than those in group B and group E (P <0.05). Group D was significantly higher than group C (P <0.05). The body weight of group D was significantly higher than that of group B, C and E. Conclusion Tiaoshu Shu granules can ameliorate the effects of atrophic gastritis in rats. The effect of NO on serum is dose-response.