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为了明确开搏通对运动性心肌肥大的作用。本实验采用游泳训练引起的大鼠心肌肥大模型，应用放射免疫及生化等方法对心肌肥大及心脏肾素－血管紧张素系统（Ｒ－Ａ－Ｓ）的变化进行了初步研究。观察到游泳五周时，大鼠心重／体重比值（Ｈ／Ｂｗｔ）显著升高，同时心肌血管紧张素Ⅱ（ＡｎｇⅡ）及心肌血管紧张素转换酶（ＡＣＥ）也明显升高。而服用开搏通的游泳大鼠心肌ＡｎｇⅡ，ＡＣＥ较单纯游泳组低，但心重／体重比值却升高。上述结果提示开搏通能抑制运动所致心肌ＡｎｇⅡ升高，但不能防止运动引起的心肌肥大。
In order to clarify the role of CAPE on exercise-induced cardiac hypertrophy. In this study, myocardial hypertrophy model induced by swimming training was used to study the changes of cardiac hypertrophy and cardiac renin-angiotensin system (R-A-S) by radioimmunoassay and biochemical methods. At 5 weeks after swimming, the H / B ratio of rats was significantly increased, while the levels of myocardial angiotensin Ⅱ (Ang Ⅱ) and myocardial angiotensin converting enzyme (ACE) were significantly increased. Myocardial Ang Ⅱ and ACE in swimming rats were lower than those in swimming group, but the ratio of heart weight to body weight increased. These results suggest that Paclitaxel can inhibit exercise-induced myocardial Ang Ⅱ increased, but can not prevent exercise-induced myocardial hypertrophy.