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本文制备透皮吸收起全身作用的异搏定凝胶,通过大鼠皮肤的吸收试验,测定了异搏定的血浆及皮肤浓度,并探讨了Azone和肉豆蔻酸异丙酯(IPM)对药物透皮吸收的促进作用。制备方法:异搏定凝胶的基本处方为异搏定盐酸盐0.216 g、Carbopol 934 0.4g、EtOH-PG(2∶1)11.5ml、水8.0 ml、1NNaOH0.5 ml、10%三乙醇胺适量。将异搏定盐酸盐溶于乙醇-丙二醇混合液(2∶1,v/v),用1 NNaOH中和,加至Carbopo1934溶液中,加入2%Azone或IPM,再加三乙醇胺使成粘稠凝胶。凝胶中异搏定的体外释放试验:对含不
In this paper, the preparation of percutaneous absorption of verapamil gel from the role of the body, through the skin absorption test to determine the verapamil plasma and skin concentrations, and to explore the Azone and isopropyl myristate (IPM) on the drug Transdermal absorption of the promotion. Preparation Methods: Verapamil gel basic prescription verapamil hydrochloride 0.216 g, Carbopol 934 0.4g, EtOH-PG (2: 1) 11.5ml, water 8.0 ml, 1NNaOH0.5 ml, 10% triethanolamine Appropriate amount. Verapamil hydrochloride was dissolved in a mixture of ethanol and propylene glycol (2: 1, v / v), neutralized with 1N NaOH, added to Carbopo 1934 solution, added with 2% Azone or IPM followed by triethanolamine Thick gel. Verapamil gel in vitro release test: Do not contain