目的探索牙周治疗对口腔幽门螺杆菌(Hp)阳性率的影响。方法选择口腔Hp阳性患者180例,随机分成三组(基础治疗+米诺环素组、基础治疗+碘甘油组、基础治疗组),实时荧光PCR检测每组1个月、3个月后口腔Hp,比较三组Hp阳性率情况。结果三组治疗后1个月、3个月口腔Hp阳性率比较差异有统计学意义(P<0.05)。结论牙周基础治疗是清除口腔Hp的有效治疗措施;配合局部应用盐酸米诺环素可增强清除口腔Hp的效果。 Objective To explore the effect of periodontal therapy on the positive rate of Helicobacter pylori (Hp) in oral cavity. Methods One hundred and eighty oral Hp positive patients were randomly divided into three groups (basic treatment + minocycline group, basal therapy + iodine-glycerol group, basic treatment group). Real-time fluorescence PCR was used to detect the oral cavity Hp, Hp positive rate of three groups were compared. Results The positive rates of oral Hp in the three groups after one month and three months were significantly different (P <0.05). Conclusions Periodontal treatment is an effective treatment for oral Hp clearance. Combined with local application of minocycline hydrochloride, it can enhance oral Hp clearance.