复方安坦加成物由穿心连内酯,亚硫酸钠、安坦组成,对慢性支气管炎有一定的疗效,本文对该药进行了毒性与药理实验。一、急性毒性试验:小鼠一次灌服加成复方安坦20g/kg。观察十天,无一例死亡。腹腔注射的 LD_(50)为3.65g/kg。犬一次灌服 2g/kg 时对血压、呼吸、心电图无影响。二、大白亚鼠急性试验表明:动物口服加成复方安坦每日1g/kg,连续30日,总量为 The compound Antan adducts consisted of penicillin, sodium sulfite and antan, which have certain curative effect on chronic bronchitis. The toxicity and pharmacological experiments of this drug were carried out in this paper. First, the acute toxicity test: The mice were fed with an additive compound Antan 20g/kg. Observed for ten days, no one died. The intraperitoneal injection of LD_(50) was 3.65 g/kg. Dogs fed 2 g/kg once had no effect on blood pressure, respiration, and ECG. 2. The acute test of Dabaiya mouse showed that the animal oral plus compound Antan daily 1g/kg, for 30 days, the total