患者刘某、住院号0342,男性,33岁,已婚,农民。因皮肤变黑3年,复发性软弱、无力、噁心、呕吐、腹痛及烦燥不安于1964年4月19日入院。缘患者2年前全身皮肤变黑、逐日易疲乏、软弱无力、精神差、体重减轻及腹痛,于1963年7月13日第一次入院,入院诊断为原发性肾上腺皮质机能减退,使用氢化可的松治疗后腹痛消失,精神好转,胃口如常出院。出院后能参加中等劳动。此次入院前3天,因劳累过渡,引起疲乏无力,不思饮食,剧烈呕吐、昏迷而再急诊入院。入院检查:体温35.4℃,脉搏110,血压70/50,神志昏迷,不合作,全身皮肤棕黑,皮肤干燥,弹性差,眼球深陷,巩膜无黄疸、瞳孔等大,对光调节反应存在。颈软,两肺呼吸音清晰,心搏较弱,心率110,无心杂音。腹舟状、软,肝、脾未触及。膝反射消失,无病理神经反射。X线报告心肺阴性。大小便常规检查阴性。红细胞318万,血色 Patient Liu, hospital number 0342, male, 33 years old, married, farmer. Blackening of the skin for 3 years, recurrent weakness, weakness, nausea, vomiting, abdominal pain and irritability on April 19, 1964 admission. 2 years ago, the skin of patients with systemic darkening, daily fatigue, weakness, poor energy, weight loss and abdominal pain, on July 13, 1963 first admission, admission was diagnosed as primary adrenocortical hypofunction, the use of hydrogenation Cortisone disappeared after treatment of abdominal pain, mental improvement, as usual discharge of appetite. After discharge to participate in moderate labor. 3 days before the admission, due to fatigue transition, causing fatigue, unable to diet, severe vomiting, coma and then emergency admission. Admission examination: body temperature 35.4 ℃, pulse 110, blood pressure 70/50, mind coma, noncooperation, systemic skin brown, dry skin, poor elasticity, eye deep, scleral jaundice, pupil and other large, the light regulation reaction exists. Neck soft, clear breath sounds of both lungs, weak heartbeat, heart rate 110, moodless murmur. Abdominal boat, soft, liver, spleen not touched. Knee reflex disappeared, no pathological reflex. X-ray cardiopulmonary negative. Regular urine test negative. Erythrocyte 3180000, color