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目的探讨不良孕产史患者细胞遗传学分析的意义。方法对1174例不良孕产史患者进行外周血淋巴细胞培养,G显带技术,染色体核型分析。结果1174例患者检出染色体核型异常61例,检出率5.20%,其中1013例妊娠胎儿丢失的夫妇中,检出异常核型40例,检出率为3.94%;76例生育过畸形儿夫妇中检出异常核型4例,检出率5.26%;40例原继发闭经患者中,检出异常核型7例,检出率17.50%;45例严重少精无精子症患者中检出异常核型11例,检出率24.44%。结论不良孕产史患者中染色体异常的发生率明显高于普通人群。对不良孕产史患者进行细胞遗传学检查,在提倡优生优育的今天具有十分重要的意义。
Objective To investigate the significance of cytogenetic analysis in patients with poor pregnancy history. Methods 1174 cases of poor pregnancy history of patients with peripheral blood lymphocyte culture, G banding technology, chromosome karyotype analysis. Results 1174 cases of chromosome abnormalities were detected in 61 cases, the detection rate was 5.20%, of which 1013 cases of missing gestational fetal couples detected abnormal karyotype in 40 cases, the detection rate was 3.94%; 76 cases of over-birth children Four cases of abnormal karyotype detected in couples, the detection rate of 5.26%; 40 cases of the original secondary amenorrhea patients, abnormal karyotype detected in 7 cases, the detection rate was 17.50%; 45 cases of severe oligozoospermia in the seizure 11 cases of abnormal karyotype, the detection rate was 24.44%. Conclusion The incidence of chromosomal abnormalities in patients with adverse pregnancy history was significantly higher than that of the general population. Cytogenetic examination of patients with adverse pregnancy history, in promoting eugenics and fertility today is of great significance.