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目的肝功能不全患者较易发生细菌感染，而肝脏又是体内药物代谢的最重要器官，用药不当易发生毒性反应，对肝功能不全住院患者抗菌药物的临床应用情况进行分析，评价其用药的合理性。方法采用回顾性调查方法，对2011年165例患有肝功能不全患者的住院情况做研究，根据WHO推荐的规定日剂量(DDD值)，药物利用指数(DUI)以及血浆白蛋白（ALB）、血内总胆红素（TB）、凝血酶原时间、谷丙转氨酶（ALT）、腹水及肝性脑病的情况对有使用抗菌药物的患者病历进行统计分析。结果165例肝功能患者中有113例有使用抗菌药物，其中治愈27例，占23.89%，病情好转78例，占69.03%；未愈8例，占6.19%，死亡1例，占0.88%；且D U I值没有大于1。结论医院肝功能不全患者使用抗菌药物比较合理，没有出现明显的药物不良反应。肝功能不全患者选用抗菌药应根据患者的具体情况制定用药方案，及时进行药物浓度监测。“,” Objective Patients with liver dysfunction are prone to bacterial infection, liver is the most important organs of liver drug metabolism in vivo, inappropriate use of drugs is prone to toxic reactions. So analysis of use of antimicrobial drugs by hospitalized patients with liver dysfunction is necessary in order to evaluate the rationality of drug’s using. Method:Using the review investigation method, investigated 165 cases of hospitalized patients with liver dysfunction at some hospitals in2011. According to the provisions of WHO recommended daily dose (DDD value), Drug utilization index (DUI) and plasma albumin (ALB), total bilirubin in the blood (TB), prothrombin time, glutamic pyruvic transaminase (ALT), ascites and hepatic encephalopathy in the case, statistical y analyzed the use of antimicrobial drugs in patients. Results: Among the 165 cases of liver function, 113 cases of patients had used antibiotics, 27 cases were cured, accounting for 23.89%; 78 cases were improved, accounting for 69.03%; 8 cases weren’t cured, accounting for 6.19%; and 1 died, accounting for 0.88%. The value was not more than 1 DUI. Conclusion: The use of antimicrobial drugs by patients with liver dysfunction was reasonable in hospital, had no significant adverse drug reactions.