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目的:探讨荧光原位杂交法(FISH)在膀胱尿路上皮癌诊断中的应用。方法:选取20例非尿路上皮癌和40例膀胱尿路上皮癌的人群尿液作常规尿脱落细胞学检查和FISH检测。结果:FISH技术的敏感性为82.5%,显著高于常规尿脱落细胞学的敏感性25.0%(P<0.05);FISH技术和常规脱落尿细胞学检查的特异性均为100%,两者在特异性方面差异无统计学意义(P>0.05)。结论:荧光原位杂交法在膀胱尿路上皮癌诊断中的特异性与常规尿脱落细胞学检查一致,但其敏感性显著高于常规尿脱落细胞学检查,所以,FISH技术更有望成为膀胱尿路上皮癌无创性的诊断和检测手段。
Objective: To investigate the application of fluorescence in situ hybridization (FISH) in the diagnosis of bladder urothelial carcinoma. Methods: Urine of 20 urinary non-urothelial carcinomas and 40 urothelial carcinomas of the urinary bladder were collected for routine urinary cytology and FISH. Results: The sensitivity of FISH was 82.5%, which was significantly higher than that of conventional urine cytology (25.0%, P <0.05). The specificity of FISH and conventional cytology was 100% There was no significant difference in specificity (P> 0.05). Conclusion: The specificity of fluorescence in situ hybridization in the diagnosis of bladder urothelial carcinoma is the same as that of conventional urine cytology, but its sensitivity is significantly higher than that of conventional urine cytology. Therefore, FISH is more likely to become bladder urine Road cancer of the non-invasive diagnosis and detection methods.