【摘 要】
：
近年来,促进受损脑细胞再生成为神经系统退行性病变治疗研究的重要方向.研究人员越来越重视脑细胞损伤后的自我修复[1],对脑细胞损伤后自我修复机制和促进细胞再生的治疗手段
【机 构】
：
山东大学附属省立医院病理科,山东大学医学院病理学与病理生理学教研室
论文部分内容阅读
近年来,促进受损脑细胞再生成为神经系统退行性病变治疗研究的重要方向.研究人员越来越重视脑细胞损伤后的自我修复[1],对脑细胞损伤后自我修复机制和促进细胞再生的治疗手段的研究越来越多[2].现发现Wnt信号通路对脑细胞损伤后的再生过程有重要作用.Wnt信号通路参与生物细胞增殖分化、细胞转运、肿瘤形成等过程[3],尤其对胚胎期哺乳动物神经系统发生有重要的调控作用.神经干细胞在特定条件下可分化为不同的神经细胞,而Wnt信号通路在成年哺乳动物受到损伤性刺激后会被启动,进而促进神经干细胞再生,但Wnt信号通路在神经系统发生过程中的具体作用机制目前仍然不清楚.本文旨在探讨如何改变Wnt通路,使神经干细胞向着理想的方向增殖分化,以期为临床应用提供理论基础,进而达到治疗疾病的作用.
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