诱发实验性舌癌是很困难的,因此妨碍了对本病的病因、生物学及治疗学方面的研究。作者用82只体重在65—90克的雄性田鼠进行实验。用Salley氏提出的0.5％9,10—二甲基—1,2—苯蒽(DMBA)丙酮溶液作为化学致癌物质。先用1号倒钧髓针在舌中1/3的左侧边缘造成一损伤区,然后涂抹DMBA溶液,每三周一次,直到产生癌为止。 It is very difficult to induce experimental tongue cancer and thus hinder the study of the etiology, biology and therapeutics of this disease. The authors used 82 male voles weighing 65-90 grams to perform experiments. Salley’s 0.5% 9,10-dimethyl-1,2-benzoquinone (DMBA) acetone solution was used as a chemical carcinogen. First, use a No. 1 inverted medullar needle to create a lesion on the left 1/3 of the left side of the tongue, and then apply the DMBA solution every three weeks until cancer is produced.