通过环氧氯丙烷活化（１，４）２氨基２脱氧βＤ葡萄糖（壳聚糖）制备免疫吸附剂，详细讨论了环氧氯丙烷活化过程的影响因素，确定了活化的最佳条件．活化（１，４）２氨基２脱氧βＤ葡萄糖树脂对单克隆抗体的偶联率为１７６％，对含乙型肝炎表面抗原阳性血清的吸附实验表明，制备的免疫吸附剂能使阳性转为阴性，吸附率为４４％． Activated by epichlorohydrin (1,4)  2  2  amino 2  deoxy  β  D  glucose (chitosan) preparation of immunosorbent, the influencing factors of epichlorohydrin activation process was discussed in detail to determine Activation of the best conditions. Activated (1,4)  2  amino  2  deoxy β  D  dextran glucose monoclonal antibody coupling rate of 17  6%, containing hepatitis B surface antigen-positive serum adsorption experiments showed that the prepared Immune adsorbent can make the positive turned negative, the adsorption rate was 44%.