白介素-33(IL-33)是近年来新发现的IL-1家族的新成员,通过结合其受体ST2诱导Th2型细胞因子的产生。IL-33既可以调节Th2型免疫反应、刺激肥大细胞产生前炎性因子,又可以作为核因子调控基因转录。IL-33在血管性疾病、变态反应性疾病、自身免疫性疾病和炎症性疾病中均发挥重要作用。对IL-33功能及机制的研究将有助于进一步了解这些疾病的致病机制,为疾病治疗提供新的策略。 Interleukin-33 (IL-33) is a new member of the newly discovered IL-1 family in recent years that induces Th2-type cytokine production by binding to its receptor, ST2. IL-33 can regulate Th2-type immune response, stimulate mast cells produce proinflammatory cytokines, but also as a nuclear factor regulating gene transcription. IL-33 plays an important role in vascular diseases, allergic diseases, autoimmune diseases and inflammatory diseases. The study of IL-33 function and mechanism will help to further understand the pathogenesis of these diseases and provide new strategies for disease treatment.