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目的研究急性脑梗死患者血尿酸水平及其与颈动脉粥样硬化的关系。方法检测112例急性脑梗死患者(梗死组)与56例健康体检者(对照组)的血尿酸(BUA)、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C),颈动脉内中膜厚度(IMT)及颈动脉粥样斑块情况。结果梗死组BUA、FPG、TG、LDL-C均高于对照组(P<0.05)。颈动脉IMT及颈动脉斑块数较对照组明显升高(P<0.05),并且BUA水平随颈动脉病变程度的加重逐步升高(P<0.05)。结论血BUA水平与脑梗死、颈动脉粥样硬化有一定相关关系,BUA是脑梗死独立危险因素。
Objective To study the relationship between serum uric acid level and carotid atherosclerosis in patients with acute cerebral infarction. Methods The levels of blood urea nitrogen (BUA), fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TG), high density HDL-C, LDL-C, carotid intima-media thickness (IMT) and carotid artery plaque. Results BUA, FPG, TG, LDL-C in infarction group were higher than those in control group (P <0.05). The carotid artery IMT and carotid artery plaque number were significantly higher than those in the control group (P <0.05), and BUA level gradually increased with the severity of carotid artery disease (P <0.05). Conclusion The level of blood BUA is related to cerebral infarction and carotid atherosclerosis. BUA is an independent risk factor for cerebral infarction.