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目的：以整体的观点，探讨Ⅱ型糖尿病血管病变与纤溶酶原激活物（ｔ Ｐ Ａ） 及抑制物（ Ｐ Ａ Ｉ－ １） 之间的关系。方法：选取４６ 例正常人，７１ 例Ⅱ型糖尿病患者，采用酶联免疫吸附法（ Ｅ Ｌ Ｉ Ｓ Ａ） 定量测定ｔ Ｐ Ａ 及 Ｐ Ａ Ｉ－ １ 水平。结果：单纯糖尿病组（ Ｄ Ｍ 组） ， Ｐ Ａ Ｉ－ １ 正常；并发血管病变各组， Ｐ Ａ Ｉ－ １ 比对照组升高，差异显著；合并大血管病变组（ Ｄ Ｍ＋ Ａｔｈ 组） ， Ｐ Ａ Ｉ－ １ 比 Ｄ Ｍ 组升高，差异显著；合并微血管病变组（ Ｄ Ｍ＋ Ｄ Ｎ／ Ｄ Ｒ 组） ， Ｐ Ａ Ｉ－ １ 有升高趋势，但差异不显著（ Ｐ＝ ０ ．０６７６） ； Ｄ Ｍ 组、 Ｄ Ｍ＋ Ａｔｈ 组、 Ｄ Ｍ＋ Ｄ Ｎ／ Ｄ Ｒ 组，ｔ Ｐ Ａ 比正常对照组升高，差异不显著； Ｄ Ｍ＋ Ａｔｈ组、 Ｄ Ｍ＋ Ｄ Ｎ／ Ｄ Ｒ 组，ｔ Ｐ Ａ 比 Ｄ Ｍ 组下降，差异不显著。多元回归分析结果显示， Ｐ Ａ Ｉ－ １ 与空腹胰岛素呈显著正相关关系。结论：（１） Ⅱ型糖尿病合并血管病变者 Ｐ Ａ Ｉ－ １ 水平升高；（２） Ｐ Ａ Ｉ－ １ 水平与空腹胰岛素水平呈显著正相关关系；（３） 推测ｔ Ｐ Ａ 在糖尿病血管病变的发病中系一代偿因素。
OBJECTIVE: To investigate the relationship between type 2 diabetic vascular lesions and plasminogen activator (t P A) and its inhibitor (P A I-1) in a holistic way. Methods: Forty six normal subjects and 71 patients with type Ⅱ diabetes mellitus were selected. The level of t P A and P A I-1 was quantified by enzyme-linked immunosorbent assay (ELISA). Results: Diabetes mellitus (D M group) and P A I-1 were normal in each group. P A I-1 in each group was significantly higher than that in the control group P A I-1 was higher than that of D M group, and the difference was significant. In the group of combined microangiopathy (D M + D N / D R), P A I-1 had an increasing trend, but the difference was not significant (P = 0.0676 ); D M group, D M + Ath group, D M + D N / D R group, t P A higher than the normal control group, the difference was not significant; D M + Ath group, D M + D N / D R group, t P A than D M group decreased, the difference was not significant. Multiple regression analysis showed that there was a significant positive correlation between P A I-1 and fasting insulin. Conclusions: (1) The level of P A I-1 is elevated in patients with type II diabetes mellitus with vascular disease; (2) The level of P A I-1 is positively correlated with fasting insulin; (3) The incidence of disease is a compensatory factor.