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目的 前瞻性对照组研究 4种引产方法的时效及对母儿的影响 ,了解血前列腺素E水平变化与引产方式的关系。方法 将 12 4例孕足月单胎头位具有引产指征、宫颈评分≤ 4分的孕妇随机分组 ,其中催产素组 2 8例 ,水囊组 2 8例 ,米索前列醇组 2 5例 ,前列腺素E2 凝胶组 43例。各种方法使用后如宫颈评分≥ 7分则行人工破膜。各组产妇在用药前、用药后 6小时、宫口开全分别取血 ,用放免法查血PGE水平。统计学分析引产时效、母儿并发症及血PGE水平与分娩的关系。结果 四组病人母儿并发症无明显差异 ,而米索前列醇组及前列腺素E凝胶组可明显改善宫颈评分 ,缩短引产至分娩时间 ,减少催产素用量。结论 PGE类引产药物安全有效 ;水囊引产经济可靠 ,临床上正逐步取代传统的催产素静滴引产。
Objective To investigate the effects of four kinds of induction of labor on maternal and neonatal effects in prospective control group and to find out the relationship between the changes of blood prostaglandin E and the induction of labor. Methods Totally 124 pregnant women with full-term pregnancy with single fetus head had indications for induction of labor. Pregnant women with cervical score ≤ 4 were randomly divided into two groups. Among them, 28 were oxytocin group, 28 in hydrocephalus group and 25 in misoprostol group , Prostaglandin E2 gel group of 43 cases. After using a variety of methods such as cervical score ≥ 7 points then the artificial rupture of the membrane. Maternal groups in each group before medication, 6 hours after treatment, cervix were taken full of blood, using radio immunoassay PGE levels. Statistical analysis of induction of labor, maternal and child complications and blood PGE levels and childbirth relations. Results There was no significant difference in the complications between mother and child in the four groups. The misoprostol group and prostaglandin E gel group could significantly improve cervical score, shorten the time from labor to delivery and reduce the dosage of oxytocin. Conclusions PGE is safe and effective in inducing abortion drugs. It is economical and reliable to induce abortion with water bag. Clinically, it is gradually replacing the traditional oxytocin intravenous drip induction.