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制造动物实验性胃癌模型对观察胃癌的发生、发展以及寻找新的诊断和治疗方法有重要的意义。过去由于没有找到适当的致癌方法,动物模型的成功率不高,直到六十年代后期才应用甲基硝基亚硝基胍(MNNG)加入水中喂饲动物,可在较短时间内成功地造成动物的胃癌。这一方法是英国 Schoen-thal和日本 Suqimura所首创。先用于小鼠,以后用狗造成胃癌模型。但是 MNNG的致癌性较强,当动物致胃癌时,小肠内往往也产生肉瘤。我们首先用ENNG(乙基硝基亚硝基胍)作为致癌剂,将其溶液与固体饲料拌和。因为固体饲料在胃内停留时间长,吸收慢,易致胃癌。所用动物是一种小种猎犬(Bea-
The manufacture of animal experimental gastric cancer models is of great significance for the observation of the occurrence and development of gastric cancer and the search for new diagnostic and therapeutic methods. In the past, due to the failure to find a suitable carcinogenic method, the success rate of animal models was not high. It was not until the late 1960s that the use of methyl nitrosoguanidine (MNNG) in water to feed animals could be successfully caused in a relatively short period of time. Animal stomach cancer. This method was pioneered by Schoen-thal of the United Kingdom and Suqimura of Japan. First used in mice, and then using a dog to create a gastric cancer model. However, the carcinogenicity of MNNG is relatively strong. When animals cause gastric cancer, sarcomas often develop in the small intestine. We first used ENNG (Ethylnitronitrosoguanidine) as a carcinogen and mixed the solution with solid feed. Because solid food stays in the stomach for a long time, it absorbs slowly and is prone to stomach cancer. The animal used is a small breed Hound (Bea-