丙型肝炎病毒(HCV)可引起肝炎、肝硬化和肝癌等一系列肝脏疾病,且慢性化几率较高。目前全世界HCV感染人数仍呈增加趋势,因此科学家对HCV的研究高度重视。HCV有一个大的开放阅读框编码约三千多个氨基酸的多聚蛋白,经蛋白酶裂解为十个多肽片段;氨基末端为结构蛋白包括有核心蛋白 Hepatitis C virus (HCV) can cause a series of liver diseases such as hepatitis, liver cirrhosis and liver cancer, and have a higher risk of chronicity. At present, the number of HCV infection in the world is still on the rise, so scientists attach great importance to the study of HCV. HCV has a large open reading frame (ORF) encoding a polyprotein of about 3000 amino acids that is cleaved by protease into ten polypeptide fragments; the amino terminus is a structural protein that includes a core protein