HBcAg 是 Dane 颗粒的核心部分的组成成分,为乙肝病毒复制的重要指标。我科先后应用 RIA 及 ELISA 法检测 HBcAg 阳性的乙型肝炎患者94例,其中28例血清 HBcAg 阳性,检出率为29.8%,同时以 HBeAg、DNAP、抗-HB_c 等感染指标进行比较,显示出一定的敏感性及特异性,并可应用于临床作为估计传染性、预后及抗病毒药物疗效观察的较好指标,特别是 ELISA 法不要特殊的仪器设备更适于推广应用。 HBcAg is the core component of Dane particles, an important indicator of hepatitis B virus replication. Our department has detected 94 cases of HBcAg-positive hepatitis B patients by RIA and ELISA, of which 28 cases were positive for HBcAg, the detection rate was 29.8%, at the same time compared with HBeAg, DNAP, anti-HBc and other indicators of infection, A certain sensitivity and specificity, and can be used in clinical as a good indicator to evaluate the efficacy of infectious, prognosis and antiviral drugs, especially the ELISA method does not require special equipment more suitable for the promotion and application.