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目的对阻断颈部淋巴引流大鼠的心血管系统整体调节功能变化进行无创性评价。方法将Wistar大鼠分两组 :对照组(n=10)接受假手术;淋巴引流阻断组(n=10)结扎颈浅及颈深淋巴管并摘除淋巴结以造成淋巴性脑水肿。两组均在术后第7d进行正立位及倒立位倾斜应激试验 ,其间连续测定动脉血压、心率、Ⅱ导ECG、顶部EEG及其能量曲线等变化 ,并计算整体压力感受器反射灵敏度(BS)。部分动物阻断两侧颈总动脉 ,观察脑电图变化及窦弓反射引起的血压变化。结果对照组正立位初 ,动脉血压降低 ,尔后迅速恢复正常。倒立位初 ,动脉血压升高 ,但随后迅速回降。当阻断两侧颈总动脉血流时 ,动脉血压升高 ,EEG不变 ,淋巴组正立位及倒立位时大鼠动脉血压均持续显著低于正常水平 ,出现心律紊乱。BS减小。阻断两侧颈总动脉后动脉血压反而降低 ,脑电图变平坦 ,脑电能量曲线几乎减小至零。结论大鼠颈淋巴引流障碍 ,可导致心血管系统整体调节功能减弱 ,压力感受器灵敏度减小 ,易产生体位性低血压。脑组织对不完全性脑缺血耐受性减弱
Objective To evaluate noninvasive changes in the overall regulatory function of the cardiovascular system in blocking lymphatic drainage of the neck. Methods Wistar rats were divided into two groups: the control group (n = 10) undergoing sham operation; the lymphatic drainage block group (n = 10) ligation of cervical superficial and cervical deep lymphatic vessels and removal of lymph nodes to cause lymphatic brain edema. In both groups, orthostatic and inverted tilt stress tests were performed on the 7th day after operation, and arterial blood pressure, heart rate, Ⅱ-lead ECG, EEG at the top, and energy curve were continuously measured during the test. The overall baroreceptor reflex sensitivity ). Some animals blocked both sides of the common carotid artery to observe changes in EEG and sinus arrhythmia caused by blood pressure changes. Results The control group orthostatic early, arterial blood pressure decreased, and quickly returned to normal. Inverted position early, arterial blood pressure increased, but then quickly dropped back. When blocking the common carotid arteries on both sides, the arterial blood pressure increased, while the EEG was unchanged. The arterial blood pressure in the upright position and upside down position of the lymphoid group continued to be significantly lower than the normal level, causing arrhythmia. BS decreases. After blocking the common carotid artery on both sides but lower arterial blood pressure, EEG flatten, EEG energy curve is almost reduced to zero. Conclusion The cervical lymphatic drainage disorder in rats can result in weakened cardiovascular system overall regulation, reduced sensitivity of baroreceptors, and proneness to orthostatic hypotension. Brain tissue impairs tolerance to incomplete cerebral ischemia