阿霉素是一种蒽环类抗生素,抗瘤谱广。在人和动物中,多次应用可引起心肌退行性变和心力衰竭。阿霉素所致心力衰竭与用药的总剂量有关,因而建议阿霉素的总剂量不超过550毫克/平方米;然而,这样会使部份可以耐受更高剂量的患者不能得到足量的应用。虽然心力衰竭的发生似常突然,但在累积量远较为较低时,已有左室功能不良。这提示阿霉素所致心肌病变,实际上在有临床征象前早已开始,有可能用预测性试验来发 Adriamycin is an anthracycline antibiotic, broad spectrum anti-tumor. In humans and animals, multiple applications can cause myocardial degeneration and heart failure. Adriamycin-induced heart failure is related to the total dose of medication and therefore a total dose of doxorubicin is recommended not to exceed 550 mg / m 2; however, this would result in patients who can tolerate a higher dose in some cases not being able to get adequate application. Although heart failure occurs frequently and suddenly, left ventricular dysfunction is present when the cumulative amount is much lower. This suggests that adriamycin-induced cardiomyopathy, in fact, before the clinical signs have already begun, it is possible to use predictive tests to send