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胶原的特征之一是脯氨酸和羟脯氨酸的含量较高。羟脯氨酸几为哺乳动物的胶原所特有,它在血清及尿中的水平可反映在胶原代谢转换较高的组织中胶原的代谢程度。在某些胶原合成活跃的病理情况下,游离脯氨酸池也有所改变。如在肝硬化患者的肝脏,游离脯氨酸池的增加与肝纤维化的程度是成比例的。本文的目的在于确定酒精性肝硬化患者血清中游离脯氨酸及羟脯氮酸的水平能否反映肝内纤维组织的代谢状态。对71例肝病患者及62例对照者的血清游离脯氨酸及游离羟脯氨酸进行了测定。肝病组包括60例肝硬化和11例慢性活动性肝病患者。肝硬化患者中有
One of the features of collagen is the high content of proline and hydroxyproline. Hydroxyproline is typical of mammalian collagen and its serum and urine levels reflect the degree of collagen metabolism in tissues with higher collagen metabolism. In some active pathological collagen synthesis, free proline pool also changed. As in the liver of patients with cirrhosis, the increase in free proline pool is proportional to the degree of liver fibrosis. The purpose of this article is to determine whether serum levels of free proline and hydroxyproline in patients with alcoholic cirrhosis reflect the metabolic status of intrahepatic fibrous tissue. Serum free proline and free hydroxyproline in 71 patients with liver disease and 62 controls were measured. Liver disease group includes 60 patients with cirrhosis and 11 patients with chronic active liver disease. There are patients with cirrhosis