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目的:观察结直肠癌组织中趋化因子巨噬细胞炎性蛋白-2(MIP-2)和单核细胞趋化蛋白-1(MCP-1)蛋白的表达,分析其表达的临床病理意义。方法:收集结直肠癌病例的病理资料和临床资料,应用免疫组织化学SP法检测待测蛋白的表达。结果:MIP-2在癌旁肠组织组和腺癌组的阳性表达率分别为76%,68%,差异无统计学意义。MCP-1在癌旁肠组织组和腺癌组的阳性表达率分别为56%,72%,差异无统计学意义。MIP-2表达与淋巴结转移有关,而与肿块大小、部位、分化程度、浸润肠壁深度无关。MCP-1表达与肿块直径、浸润肠壁深度、淋巴结转移有关,而与部位、分化程度无关。结论:MIP-2和MCP-1在结直肠癌中的表达主要与侵袭和转移相关。
OBJECTIVE: To observe the expression of chemokines macrophage inflammatory protein-2 (MIP-2) and monocyte chemoattractant protein-1 (MCP-1) in colorectal cancer tissues and to analyze the clinicopathological significance. Methods: The pathological data and clinical data of colorectal cancer cases were collected. The expression of the protein under test was detected by immunohistochemical SP method. Results: The positive expression rates of MIP-2 in para-cancerous tissue and adenocarcinoma group were 76% and 68%, respectively, with no significant difference. The positive rates of MCP-1 in the para-cancerous tissue and adenocarcinoma group were 56% and 72%, respectively, with no significant difference. MIP-2 expression and lymph node metastasis, but with the size of the tumor, location, degree of differentiation, infiltration of intestinal wall depth has nothing to do. The expression of MCP-1 was related to the diameter of tumor, the depth of infiltrating bowel wall, and the lymph node metastasis, but not to the degree and location of differentiation. Conclusion: The expression of MIP-2 and MCP-1 in colorectal cancer is mainly associated with invasion and metastasis.