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有强心作用的地高辛,其药理作用的主要机制是抑制心肌细胞膜上的钾钠ATP酶,进而抑制心肌细胞膜上钠泵的运转,结果使钠泵将心肌细胞外K+打进细胞内的作用,以及将细胞内的Na+打到细胞外的作用减弱,使心肌细胞内的Na+浓度轻度升高。心肌细胞内Na+浓度的这种轻度升高将增加心肌细胞膜上钠钙交换体的活性,使较多的Na+经该交换体打到细胞外,同时交换回更多的Ca2+进入心肌细胞内。
Digoxin cardiac function, the main mechanism of its pharmacological effects is to inhibit myocardial cell membrane potassium sodium ATP enzyme, thereby inhibiting the myocardial cell membrane sodium pump operation, the results of the sodium pump cardiocyte K + into the cell Role, as well as the role of intracellular Na + extracellular weakening, so that intracellular Na + concentration increased slightly. This mild increase in Na + concentration in cardiomyocytes increases the activity of Na + / Ca2 + exchangers on the membrane of cardiac myocytes, causing more Na + to break out of the cell via this exchanger, while exchanging more Ca2 + into the cardiomyocytes.