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目的分析标准化~(131)I治疗不同年龄段Grave’s甲亢的效果。方法 70例Grave’s甲亢患者,根据患者年龄段分为观察组(>60岁)和对照组(>20岁),每组35例。两组患者均采用标准化~(131)I治疗,比较两组患者治疗后的游离甲状腺素、游离三碘甲状腺原氨酸水平变化、总有效率和甲状腺功能减退症(甲减)发生率。结果观察组患者治疗后的游离甲状腺素(15.24±1.26)pmol/L、游离三碘甲状腺原氨酸水平(4.32±0.12)pmol/L明显优于对照组的(29.35±2.15)、(18.68±3.71)pmol/L,差异均具有统计学意义(P<0.05)。观察组治疗总有效率(85.71%)高于对照组的(62.86%);观察组治疗后甲减发生率(8.57%)低于对照组的(34.29%),差异均具有统计学意义(P<0.05)。结论 Grave’s甲亢老年患者给予标准化~(131)I治疗,不仅能有效改善游离甲状腺素和游离三碘甲状腺原氨酸水平,还能提高治疗效果。
Objective To analyze the effect of standardized 131I treatment of Grave’s hyperthyroidism at different ages. Methods Seventy patients with Grave’s hyperthyroidism were divided into observation group (> 60 years old) and control group (> 20 years old), 35 cases in each group. Both groups were treated with standard 131I treatment. The free thyroxine, free triiodothyronine levels, total effective rate and the incidence of hypothyroidism (hypothyroidism) were compared between the two groups after treatment. Results After treatment, the free thyroxine (15.24 ± 1.26) pmol / L and the free triiodothyronine (4.32 ± 0.12) pmol / L in the observation group were significantly better than those in the control group (29.35 ± 2.15, 18.68 ± 3.71) pmol / L, the differences were statistically significant (P <0.05). The total effective rate of observation group (85.71%) was higher than that of control group (62.86%). The incidence of hypothyroidism in observation group (8.57%) was lower than that of control group (34.29%), the difference was statistically significant <0.05). Conclusion Grave’s Hyperthyroidism elderly patients given standardized 131I treatment, not only can effectively improve the free thyroxine and free triiodothyronine levels, but also improve the therapeutic effect.