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为了探讨巯甲丙脯酸（ＣＰＴ）增加下壁心肌梗塞（ＩＮＦ）并发症和病死率的原因，在实验性心肌梗塞模型上观察了ＣＰＴ对ＩＮＦ的电生理和血液动力学作用，并与其对前壁心肌梗塞（ＡＮＴ）的作用进行比较。结果表明：（１）ＣＰＴ明显延长ＩＮＦ的窦房结恢复时间和心房、心室、房室交界区的有效不应期，同时心率减慢、房室传导阻滞发生率增加；（２）与ＡＮＴ相比，ＩＮＦ者使用ＣＰＴ后动脉压下降更为显著，左室舒末压轻度下降。作者认为：临床上ＣＰＴ治疗增加ＩＮＦ并发症和死亡率的原因与ＣＰＴ对ＩＮＦ的负性心电生理和血液动力学效应有关，因此，ＩＮＦ急性期不宜采用ＣＰＴ治疗。主题词
To investigate the reasons for the increased complications and mortality of inferior wall myocardial infarction (INF) with captopril (CPT), the electrophysiological and hemodynamic effects of CPT on INF were observed in an experimental myocardial infarction model The role of anterior myocardial infarction (ANT) was compared. The results showed that: (1) CPT significantly prolonged the sinus node recovery time and the effective refractory period of atrial, ventricular and atrioventricular junction in INF, meanwhile, the heart rate and the incidence of atrioventricular block increased; (2) In contrast, the decline in arterial pressure was more pronounced in patients with INF after CPT and the end-diastolic pressure in left ventricle slightly decreased. The authors believe that: CPT treatment of clinical reasons to increase the incidence of INF complications and mortality and CPT on INF negative ECG and hemodynamic effects, therefore, should not be used in acute phase of INF treatment of CPT. Keywords