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组织工程技术的发展为外周神经损伤提供了新的治疗方法[1],尤其在较长的外周神经缺损中可以解决自体神经移植供源不足的问题。近些年研究表明,施万(Schwann)细胞在外周神经发育和促进外周神经的再生和修复中起着重要的作用[2-3]。施万细胞作为外周神经组织工程中重要的种子细胞之一,但是自体来源的施万细胞数量和增殖能力有限,不能满足组织工程化的需要,因此获得充足的细胞用于移植成了问题的关键。骨髓间充质干细胞(bone
The development of tissue engineering technology provides a new treatment for peripheral nerve injury [1], especially in the long-term peripheral nerve defects can solve the problem of autologous nerve graft insufficiency. In recent years, studies have shown that Schwann cells play an important role in the development of peripheral nerves and the promotion of peripheral nerve regeneration and repair [2-3]. Schwann cells, as one of the important seed cells in peripheral nerve tissue engineering, have limited numbers and proliferative capacity of Schwann cells derived from their own cells and can not meet the needs of tissue engineering. Therefore, obtaining sufficient cells for transplantation is the key issue . Bone marrow mesenchymal stem cells