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目的 探讨在配制诺氟沙星注射液过程中 ,配制液浓度、温度、p H值、加入活性碳量、加入等渗调节剂对活性碳的吸附作用的影响。方法 配制诺氟沙星不同浓度的水溶液 ,分别在 p H3 .0、p H5 .0和6 0℃、80℃的温度条件下 ,用紫外分光光度法分别测定吸附平衡后过滤脱碳的滤液的药物含量 ;加入不同的活性碳量、加入不同的等渗调节剂和等量活性碳 ,待活性碳吸附平衡后 ,过滤脱碳 ,用紫外分光光度法分别测定滤液的药物含量。结果 吸附平衡常数 K值随溶液 p H值和温度的升高而增大 ;随着加入活性碳量的增加 ,其对诺氟沙星的吸附量也增加 ,且呈线性上升 ;葡萄糖使活性碳对诺氟沙星的吸附量减少 ,而氯化钠使活性碳对诺氟沙星的吸附量增加。结论 在生产制备诺氟沙星注射液过程中 ,应注意配制液浓度、温度、p H值、加入活性碳量、加入等渗调节剂对活性碳吸附作用的影响
Objective To investigate the effects of concentration, temperature, pH value, amount of activated carbon, and isotonicity regulator on the adsorption of activated carbon during the preparation of norfloxacin injection. Methods Different concentrations of norfloxacin were prepared. The filtrate of decarbonized filtrate was determined by ultraviolet spectrophotometry at p H3 .0, p H5 .0 and temperature of 80 ℃. Drug content; adding different amount of activated carbon, adding different isotonicity adjusting agents and the same amount of activated carbon, after the activated carbon is adsorbed and equilibrated, decarburization is filtered off, and the drug content of the filtrate is respectively determined by ultraviolet spectrophotometry. Results The equilibrium constant K of adsorption increased with the increase of pH and temperature of solution. With the increase of the amount of activated carbon, the adsorption amount of norfloxacin also increased and linearly increased. When glucose activated carbon Adsorption of norfloxacin decreased, while sodium chloride activated carbon adsorption of norfloxacin increased. Conclusions In the process of producing norfloxacin injection, attention should be paid to the influence of the concentration of formulation solution, temperature, p H value, the amount of activated carbon added and the isotonicity adjusting agent on the adsorption of activated carbon