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目的观察栀早颗粒治疗女童中枢性早熟临床疗效,指导临床治疗女童中枢性早熟的用药。方法选择2014年1月-2016年1月吉林大学中日联谊医院收治的中枢性性早熟女童。随机分为观察组(栀早颗粒治疗)与对照组(醋酸亮丙瑞林治疗),每组各54例。观察组患童口服栀早颗粒,对照组患童静脉注射醋酸亮丙瑞林微球,两组患童均治疗3个月。比较两组患童临床疗效,治疗前及治疗结束后性激素水平,包括黄体生成素(LH)、卵泡刺激素(FSH)及雌二醇(E2)及生长指标改善情况,并记录与用药相关不良反应发生情况。结果治疗后,观察组患童的总有效率为88.89%,对照组患童的总有效率为90.74%,两组患童间的有效率无显著差异(P>0.05)。治疗结束后,两组患童FSH、E2、LH水平与治疗前比较均降低,差异有统计学意义(P<0.05);其中,观察组改善情况优于对照组(P<0.05)。治疗结束后,两组患童骨龄降低,身高增加,体重增加,差异有统计学意义(P<0.05);其中,观察组改善情况优于对照组(P<0.05)。观察组不良反应显著低于对照组(P<0.05),差异有统计学意义。结论栀早颗粒治疗女童中枢性早熟临床疗效较为理想,能够抑制或减缓中枢性性早熟女童垂体促性腺激素和性腺性激素分泌,延缓骨龄的增长速度,值得进一步研究推广。
Objective To observe the clinical efficacy of Zhizao granule in the treatment of central precocious puberty in girls and to guide the clinical treatment of central precocious puberty in girls. Methods From January 2014 to January 2016, the Central precocious girls admitted to Sino-Japanese Friendship Hospital of Jilin University. Randomly divided into observation group (Zhizao granule treatment) and control group (leuprolide acetate treatment), each group of 54 cases. Observation group of children oral Zhizao particles, the control group of children intravenous injection of leuprolide acetate microspheres, both groups of children were treated for 3 months. The clinical efficacy of the two groups of children was compared. The levels of sex hormones including luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol (E2) and growth index before treatment and after treatment were compared. Reaction occurred. Results After treatment, the total effective rate of the observation group was 88.89%, while that of the control group was 90.74%. There was no significant difference between the two groups (P> 0.05). After the treatment, the levels of FSH, E2 and LH in both groups were significantly lower than those before treatment (P <0.05), and the improvement in the observation group was better than that in the control group (P <0.05). After treatment, the bone age, height and weight of the two groups were significantly decreased (P <0.05). The improvement of the observation group was better than that of the control group (P <0.05). Adverse reactions in observation group were significantly lower than those in control group (P <0.05), the difference was statistically significant. Conclusion Zhizao granule treatment of girls with central precocious palliative clinical effect is more ideal, can inhibit or slow the central precocious puberty gonadotropin and gonadal sex hormone secretion, delay the growth of bone age, it is worth further study and promotion.