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目的:应用线性扫描伏安法和循环伏安法研究了头孢拉定的电化学行为。结果:头孢拉定在pH=6.0的0.1 mol/L柠檬酸钠-氢氧化钠介质中,在+0.23V(vs.Ag/AgC1)电位处产生一灵敏的阳极氧化峰,应用DPV法进行测定,该峰电流值ip与头孢拉定浓度在3.75×10-5~1.5×10-4mol/L范围内有良好的线性关系(r=0.9950),据此建立了伏安法检测头孢拉定的方法,检出限为2.5×10-6mol/L,样品测定平均加标回收率达97.50%,RSD=7.48%。结论:同时,研究发现头孢拉定的电极过程为受吸附控制的不可逆过程,电极反应转移电子数为1。
OBJECTIVE: The electrochemical behavior of cephradine was studied by linear sweep voltammetry and cyclic voltammetry. Results: Cefradizime produced a sensitive anodic oxidation peak at +0.23V (vs.Ag/AgC1) potential in 0.1 mol / L sodium citrate-sodium hydroxide solution at pH 6.0. The DPV method was used to determine The peak current value ip and cefradine concentration in the 3.75 × 10-5 ~ 1.5 × 10-4mol / L range has a good linear relationship (r = 0.9950), thus establishing a voltammetric detection cefradine method, the detection limit 2.5 × 10-6mol / L, the average recovery of the sample was 97.50%, RSD = 7.48%. Conclusions: At the same time, it was found that cefradine electrode process is an irreversible process controlled by adsorption, and the number of electrons transferred by electrode reaction is 1.