Objective:To investigate the prevalence of microbial antigenic components of circulating immune complexes amongst grades of CD4 T lymphocyte counts in HIV sero positive and seronegative participants.Methods:Polyethelene glycol(PEG-600) and buffering methods of precipitation and dissociation of immune complexes was used to generate immune solution from sera of 100 HIV sero-positive and 100 HIV sero-negative participants.These were categorized into 3 grades based on CD4 count:> 500 cell/mm,200-499 cell/mm3 and <200 cell/mm3.The immune solutions were assayed using membrane based immunoassay and antibody titration, along side its unprocessed serum for detection of various microbial antigens and or antibodies. CD4 T cell counts were estimated using Patec Cyflow SL-3 Germany.Results:Antigenic component of immune complexes of various infectious agents was detected in 99 and 70 HIV seropositive and HIV sero-negative participants,respectively.In group A,there were 10 HIV positive participants,including 4(40.0%) had circulating immune complexes(CICs) due to Salmonella species only:1(10.0%) due to Salmonella-Plasmodium falciparum(P.falciparum),SalmonellaP. falciparum-HCV and P.falciparum antigens,respectively.In group B,45(45.4%) HIV seropositive participants with CICs had CD4 T lymphocyte count between 200-499 cells/mm~3.Out of these,20(44.4%) had CICs due to Salmonella species only:9(20%) due to Salmonella-P. falciparum.In group C,there were 44(44.4%) HIV sero-positive participants,including 3(6.8%) due to Salmonella species only:24(54.4%) due to Salmonella-P.falciparum:2(4.5%) due to P. falciparum only.Conclusions:In HIV sero-positive participants,presence of heterogeneity of Salmonella species-P.falciparum antigens was highly incriminated in CD4 count depletion but not homogeneity of malaria parasites antigens.Malaria parasites antigens only were incriminated in CD4~+ count depletion amongst HIV sero-negative participants.Before taking any decision on the management of HIV-1-positive individuals,their malaria and Salmonella paratyphi status should be assessed,but not malaria status alone. Objective: To investigate the prevalence of microbial antigenic components of circulating immune complexes amongst grades of CD4 T lymphocyte counts in HIV sero positive and seronegative participants. Methods: Polyethelene glycol (PEG-600) and buffering methods of precipitation and dissociation of immune complexes was used to generate immune solution from sera of 100 HIV sero-positive and 100 HIV sero-negative participants. These were categorized into 3 grades based on CD4 count:> 500 cells / mm, 200-499 cells / mm3 and <200 cells / mm3. The immune solutions were assayed using membrane based immunoassay and antibody titration along its unprocessed serum for detection of various microbial antigens and antibodies. CD4 T cell counts were estimated using Patec Cyflow SL-3 Germany. Results: Antigenic component of immune complexes of various infectious agents were detected in 99 and 70 HIV seropositive and HIV sero-negative participants, respectively. In group A, there were 10 HIV positive participants, i due to Salmonella species only: 1 (10.0%) due to Salmonella-Plasmodium falciparum (P. falciparum), Salmonella P. falciparum-HCV and P. falciparum antigens, respectively.In ncluding 4 (40.0%) had circulating immune complexes Groups B, 45 (45.4%) HIV seropositive participants with CICs had CD4 T lymphocyte count between 200-499 cells / mm ~ 3. Out of these, 20 (44.4%) had CICs due to Salmonella species only: 9 (20%) due to Salmonella-P. falciparum.In group C, there were 44 (44.4%) HIV sero-positive participants, including 3 (6.8%) due to Salmonella species only: 24 (54.4%) due to Salmonella-P. falciparum: 2 (4.5%) due to P. falciparum only. Conclusions: In HIV sero-positive participants, presence of heterogeneity of Salmonella species-P. falciparum antigens was highly incriminated in CD4 count depletion but not homogeneity of malaria parasites antigens. Malaria parasites antigens only were incriminated in CD4 ~ + count depletion amongst HIV sero-negative participants. Before taking any decision on the management of HIV-1-positive individuals, their malaria and Salmonella paratyphi status should be assessed, but not malaria status alone.