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Emdogain的主要成分是釉基质蛋白衍生物(enamel matrix derivative,EMD),是通过乙酸法、纯化层析法从猪恒牙胚提取获得。EMD不仅能促进无细胞性牙骨质再生,还能促进牙周膜细胞的增殖及分化,其用于牙周组织再生治疗已成为近年来牙周病领域研究的热点。文中就EMD促进牙周组织再生方面的研究及其口腔临床应用概况进行综述。
The main component of Emdogain is the enamel matrix derivative (EMD), which is obtained from porcine permanent tooth germ by acetic acid method and purification chromatography. EMD can not only promote the regeneration of acellular cementum, but also promote the proliferation and differentiation of periodontal ligament cells. The use of EMD in periodontal tissue regeneration has become a hot research topic in the field of periodontal disease in recent years. In this paper, the study on the promotion of periodontal tissue regeneration by EMD and its clinical application of oral cavity were reviewed.