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目的探索孕期妇女心脏安全性评估的新指标及心脏储备的变化。方法2008年于重庆大学生物工程学院,84名孕妇和71名非孕妇志愿受试者纳入研究。根据心脏储备的无创性监测方法,测量、计算和分析孕妇与非孕妇的心率、第1与第2心音幅值之比(S1/S2)、舒张期与收缩期的时限之比(D/S)。结果研究组孕妇的心率[(95.24±12.80)/min]与S1/S2(2.14±0.83)均比对照组妇女[(75.97±9.78)/min、1.84±0.86]升高,差异均有统计学意义(P<0.05);但研究组D/S(1.24±0.21)比对照组(1.57±0.32)降低,差异有统计学意义(P<0.05)。结论孕妇在妊娠这一应激过程中动用了心脏储备,导致心脏负担加重。上述新指标的研究将有益于孕期妇女心脏安全性的评估。
Objective To explore new indicators of cardiac safety assessment and changes of cardiac reserve in pregnant women. Methods In 2008, 84 pregnant women and 71 non-pregnant volunteers were enrolled in the Bioengineering Institute of Chongqing University. According to the noninvasive monitoring method of heart reserve, the heart rate, the ratio of the first and second heart sound amplitudes (S1 / S2), the ratio of diastolic to systolic duration (D / S ). Results Compared with the control group, the heart rate (95.24 ± 12.80) / min and S1 / S2 (2.14 ± 0.83) in the study group were significantly higher than those in the control group [(75.97 ± 9.78) /min and 1.84 ± 0.86], both of which were statistically significant (P <0.05). However, the D / S (1.24 ± 0.21) in the study group was lower than that in the control group (1.57 ± 0.32), with a significant difference (P <0.05). Conclusion Pregnant women have used heart reserve during the stress of pregnancy, resulting in heavier heart burden. The study of the above new indicators will be useful for the assessment of cardiac safety in pregnant women.