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应用带过滤罩的透明鼠笼在层流架内繁育先天性Ｔ和Ｂ淋巴细胞免疫缺陷的重度联合疫缺陷（ｓｅｖｅｒｅＣｏｍｂｉｎｅｄＩｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ，ＳＣＩＤ）小鼠获得成功。１９９３年５月自中国医学科学院实验动物研究所引进了３对ｓｃｉｄ小鼠种鼠以来，现已近交繁育至第十代共繁育ｓｃｉｄ小鼠７Ｚ０只，其寿命均超过１２个月。平均产仔数为５．５只，不育率为１４．９％，离乳率为８８．２％。ｓｃｉｄ小鼠４－１０周龄的体重与ＢＡＬＢ／ｃ小鼠相比无明显差异，微生物学检测符合ＳＰＦ级小鼠标准。解剖发现其胸腺极小，胸腺的相对重量仅为同龄ＢＡＬＢ／ｃ小鼠的６％左右；脾脏相对重量为２７－３７％；外周血淋巴细胞仅占白细胞总数的１１－２６％。应用酶联免疫酶标法测定３－４周龄和大于１０周龄的ｓｃｉｄ小鼠血清ＩｇＧ的含量均小于１×１０￣（－３）ｍｇ／ｍｌ，没有发现ｓｃｉｄ小鼠的“渗漏”现象。人癌移植于ｓｃｉｄ小鼠后获得３种人癌移植瘤：肺腺癌（ＬＡＸ－８３）、肝细胞肝癌（ＬＣ－４１２）、结肠粘液腺癌（ｃｏｌｏｎ），其平均瘤重均显著大于ＢＡＬＢ／ｃ裸小鼠。
Successful mice were grafted with severe Combined Immunodeficiency (SCID) mice with innate T and B lymphocyte immunodeficiency in a transparent cage with a filter cage. May 1993 Since the introduction of three pairs of scid mice from the Institute of Experimental Animals, Chinese Academy of Medical Sciences has been inbred to the tenth generation of co-breeding scid mice 7Z0, their life span of more than 12 months. The average number of litter size was 5.5, the rate of infertility was 14.9%, and the rate of estrus was 88.2%. There was no significant difference in the body weight of scid mice at 4-10 weeks of age compared with that of BALB / c mice. Microbiological tests were in accordance with the SPF mouse standard. Anatomical findings of the thymus is extremely small, the relative weight of the thymus is only about 6% of the same age BALB / c mice; spleen relative weight of 27-37%; peripheral blood lymphocytes only accounted for 11-26% of the total white blood cells. Serum IgG levels were less than 1 × 10 ~ (-3) mg / ml in mice of 3-4 weeks old and more than 10 weeks old by enzyme-linked immunosorbent assay. No “leakage” of scid mice was found phenomenon. Three kinds of human carcinoma xenografts were obtained after transplanted into scid mice: lung adenocarcinoma (LAX-83), hepatocellular carcinoma (LC-412) and colonic mucinous adenocarcinoma (colon) / C nude mice.